Exploring protein phosphorylation by combining computational approaches and biochemical methods
نویسندگان
چکیده
منابع مشابه
Ranking the Methods of Technology Cross-Border Acquisition, Combining TOPSIS and ANP Approaches for Model Development
Simultaneous with the industries increasing growth, thecompanies must acquire the new technologies to achieve the core competency,survival and improvement and also effectiveness in market. Choosingthe suitable acquisition mode of required technology is one of thecritical strategic decisions in the field of technology management. Dueto the importance of technology acquisition, the main objective...
متن کاملComputational Approaches to Combining Predictive Biological Models
Predictive models of gene expression are evaluated against actual expression levels of genes under various cell conditions. The results are evaluated for when a model is a good predictor and for which genes the model is a good predictor; the individual models are then combined into a multi-model having better predictive power, under more conditions, than the standalone models.
متن کاملPrediction of Protein–Protein Interactions by Evidence Combining Methods
Most cellular functions involve proteins' features based on their physical interactions with other partner proteins. Sketching a map of protein-protein interactions (PPIs) is therefore an important inception step towards understanding the basics of cell functions. Several experimental techniques operating in vivo or in vitro have made significant contributions to screening a large number of pro...
متن کاملUnderstanding protein motions by computational modeling and statistical approaches
Because of its appealing simplicity, the elastic network model (ENM) has been widely accepted and applied to study many molecular motion problems, such as the molecular mechanisms of chaperonin GroEL-GroES function, allosteric changes in hemoglobin, ribosome motions, motor-protein motions, and conformational changes in general. In this dissertation, the ENM is employed to study various protein ...
متن کاملComputational methods for diffusion-influenced biochemical reactions
MOTIVATION We compare stochastic computational methods accounting for space and discrete nature of reactants in biochemical systems. Implementations based on Brownian dynamics (BD) and the reaction-diffusion master equation are applied to a simplified gene expression model and to a signal transduction pathway in Escherichia coli. RESULTS In the regime where the number of molecules is small an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2020
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2020.06.043